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Effect of Procalcitonin-Based Guidelines vs Standard Guidelines on Antibiotic Use in Lower Respiratory Tract Infections

2009; American Medical Association; Volume: 302; Issue: 10 Linguagem: Inglês

10.1001/jama.2009.1297

1538-3598

Philipp Schüetz, Mirjam Christ‐Crain, Robert V. Thomann, Claudine Falconnier, Marcel Wolbers, Isabelle Widmer, Stefanie Neidert, Thomas Fricker, C Blum, Ursula Schild, Katharina Regez, Ronald A. Schoenenberger, Christoph Henzen, Thomas Bregenzer, Claus Hoess, Martín Krause, Heiner C. Bucher, Werner Zimmerli, Beat Müeller, for the ProHOSP Study Group,

Sepsis Diagnosis and Treatment

2][3] The most frequent indication for antibiotic prescriptions in the northwestern hemisphere is lower respiratory tract infections (LRTIs),which range in severity from self-limited acute bronchitis to severe acute exacerbation of chronic obstructive pulmonary disease (COPD), and to life-threatening bacte-rial community-acquired pneumonia (CAP). 46][7] As many as 75% of patients with LRTI are treated with antibiotics, despite the predominantly viral origin of their infection. 8 approach to estimate the probability of bacterial origin in LRTI is the measurement of serum procalcitonin (PCT).