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A global analysis of Y-chromosomal haplotype diversity for 23 STR loci

2014; Elsevier BV; Volume: 12; Linguagem: Inglês

10.1016/j.fsigen.2014.04.008

1878-0326

Josephine Purps, Sabine Siegert, Sascha Willuweit, Marion Nagy, Cı́ntia Alves, Renato Salazar, Sheila M.T. Angustia, Lorna H. Santos, Katja Anslinger, Birgit Bayer, Qasim Ayub, Wei Wei, Yali Xue, Chris Tyler‐Smith, Miriam Baeta, Begoña Martínez‐Jarreta, Balázs Egyed, Beate Balitzki, Sibylle Tschumi, David Ballard, Denise Syndercombe Court, Xinia Barrantes, Gerhard P. Bassler, Tina Wiest, Burkhard Berger, Harald Niederstätter, Walther Parson, Carey Davis, Bruce Budowle, Haran Burri, U. V. Borer, Christoph Koller, Elizeu Fagundes de Carvalho, Patricia M. Domingues, Wafaa Takash Chamoun, Michael D. Coble, Carolyn R. Hill, Daniel Corach, Mariela Caputo, María Eugenia D’Amato, Sean Davison, Ronny Decorte, Maarten Larmuseau, Claudio Ottoni, Olga Rickards, Di Lu, Jiang Cheng-tao, Tadeusz Dobosz, Anna Jonkisz, William E. Frank, Ivana Furač, Christian Gehrig, Vincent Castella, Branka Gršković, Cordula Haas, Jana Wobst, Gavrilo Hadzic, Katja Drobnič, Katsuya Honda, Yiping Hou, Di Zhou, Yan Li, Shengping Hu, Shenglan Chen, Uta-Dorothee Immel, Rüdiger Lessig, Zlatko Jakovski, Tanja Ilievska, Anja E. Klann, Cristina García, Peter de Knijff, Thirsa Kraaijenbrink, A. Kondili, P. Miniati, Maria Vouropoulou, Lejla Kovačević, Damir Marjanović, Iris Lindner, Issam Mansour, Mouayyad Al-Azem, Ansar El Andari, Miguel Marino, Sandra Furfuro, Laura Locarno, Pablo Martı́n, Gracia Luque, Antonio Alonso, Luís Souto Miranda, Helena Moreira, Natsuko Mizuno, Yasuki Iwashima, Rodrigo S. Moura Neto, T.L.S. Nogueira, Rosane Silva, Marina Nastainczyk-Wulf, Jeanett Edelmann, Michael M. Kohl, Shengjie Nie, Xianping Wang, Baowen Cheng, Carolina Núńez, Marian M. de Pancorbo, Jill K. Olofsson, Niels Morling, Valerio Onofri, Adriano Tagliabracci, Horolma Pamjav, Antónia Völgyi, Gusztáv Bárány, Ryszard Pawłowski, Agnieszka Maciejewska, Susi Pelotti, Witold Pepiński, Monica Abreu-Głowacka, Christopher Phillips, Jorge Cárdenas, Danel Rey‐González, Antonio Salas, Francesca Brisighelli, Cristian Capelli, Ulises Toscanini, A. Piccinini, Marilidia Piglionica, Stefania Lonero Baldassarra, Rafał Płoski, Magdalena Konarzewska, Emila Jastrzebska, Carlo Robino, Antti Sajantila, Jukka U. Palo, Evelyn K. Guevara, Jazelyn M. Salvador, Maria Corazon A. De Ungria, Jae Joseph Russell B. Rodriguez, Ulrike Schmidt, Nicola Schlauderer, Pekka Saukko, Peter M. Schneider, Miriam Sirker, Kyoung‐Jin Shin, Yu Na Oh, Iulia Skitsa, Alexandra Ampati, Tobi-Gail Smith, Lina Solis de Calvit, Vlastimil Stenzl, Thomas Capal, Andreas Tillmar, Helena Nilsson, Stefania Turrina, Domenico De Leo, Andrea Verzeletti, Venusia Cortellini, Jon H. Wetton, Gareth M. Gwynne, Mark A. Jobling, M.R. Whittle, Denilce R. Sumita, Paulina Wolañska‐Nowak, Rita Y.Y. Yong, Michael Krawczak, Michael Nothnagel, Lutz Roewer,

Genetic Associations and Epidemiology

In a worldwide collaborative effort, 19,630 Y-chromosomes were sampled from 129 different populations in 51 countries. These chromosomes were typed for 23 short-tandem repeat (STR) loci (DYS19, DYS389I, DYS389II, DYS390, DYS391, DYS392, DYS393, DYS385ab, DYS437, DYS438, DYS439, DYS448, DYS456, DYS458, DYS635, GATAH4, DYS481, DYS533, DYS549, DYS570, DYS576, and DYS643) and using the PowerPlex Y23 System (PPY23, Promega Corporation, Madison, WI). Locus-specific allelic spectra of these markers were determined and a consistently high level of allelic diversity was observed. A considerable number of null, duplicate and off-ladder alleles were revealed. Standard single-locus and haplotype-based parameters were calculated and compared between subsets of Y-STR markers established for forensic casework. The PPY23 marker set provides substantially stronger discriminatory power than other available kits but at the same time reveals the same general patterns of population structure as other marker sets. A strong correlation was observed between the number of Y-STRs included in a marker set and some of the forensic parameters under study. Interestingly a weak but consistent trend toward smaller genetic distances resulting from larger numbers of markers became apparent.