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Ibuprofen Microcapsules: the Effect of Production Variables on Microcapsule Properties

1994; Taylor & Francis; Volume: 20; Issue: 5 Linguagem: Inglês

10.3109/03639049409038330

1520-5762

T. Kristmundsdóttir, Kristín Ingvarsdóttir,

Advancements in Transdermal Drug Delivery

AbstractIbuprofen was microencapsulated with ethylcellulose using the solvent evaporation method. The effect of production variables on the properties of the microcapsules and drug release from them is described. Results show that size distribution, drug loading and the amount of free drug on the surface of the microcapsules is affected by production variables. The release of drug from the microcapsules was observed to be strongly influenced by parameters affecting the presence of uncoated drug on the microcapsule surface.