Correlation Between Serum Prostate Specific Antigen Levels and the Volume of the Individual Glandular Zones of the Human Prostate
1995; Lippincott Williams & Wilkins; Volume: 153; Issue: 1 Linguagem: Inglês
10.1097/00005392-199501000-00038
ISSN1527-3792
AutoresPeter Hammerer, John E. McNeal, Thomas A. Stamey,
Tópico(s)Xenotransplantation and immune response
ResumoNo AccessJournal of UrologyClinical Urology: Original Article1 Jan 1995Correlation Between Serum Prostate Specific Antigen Levels and the Volume of the Individual Glandular Zones of the Human Prostate Peter G. Hammerer, John E. McNeal, and Thomas A. Stamey Peter G. HammererPeter G. Hammerer , John E. McNealJohn E. McNeal , and Thomas A. StameyThomas A. Stamey View All Author Informationhttps://doi.org/10.1097/00005392-199501000-00038AboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail To analyze the correlation between serum prostate specific antigen (PSA) levels and the volume of the individual glandular zones of the human prostate, we examined 31 cystoprostatectomy specimens as well as 13 radical prostatectomy specimens with a prostate cancer volume of 0.3 cc or less, no bladder cancer infiltrating the prostate, no granulomas or severe inflammation, as well as no patient history of radiation, transurethral resection of the prostate or hormonal treatment. The volumes of the peripheral zone, transition zone and central zone were separately determined by outlining the zonal boundaries during microscopic examination of all slides at each level of section. PSA was measured by the Yang polyclonal assay. In the univariant regression analysis the correlation coefficients among serum PSA and transition zone, peripheral zone and central zone volumes were 0.934, 0.546 and 0.368, respectively, strongly suggesting that most PSA leakage from the prostate into the serum comes from the transition zone. The regression of serum PSA and transition zone volumes leads to a prediction of approximately 0.261 ng./ml. PSA per gm. benign prostatic hyperplasia (BPH) plus an intercept of 0.878, a number in keeping with our 1987 estimates of 0.3 ng./ml./gm. BPH. The volumes of the 3 zones appeared to be independent variables. Transition zone volume showed the greatest variation because of BPH. The mean average ratio of peripheral zone volume to central zone volume was nearly 3:1. These data strongly support the concept of age-adjusted PSA levels, since most of the increase in size of the prostate with increasing patient age comes from the transition zone from which BPH develops. References 1 : Regional morphology and pathology of the prostate. Amer. J. Clin. Path.1968; 49: 347. Crossref, Medline, Google Scholar 2 : Normal histology of the prostate. Amer. J. Surg. Path.1988; 12: 619. Google Scholar 3 : Immunohistochemical localisation of prostate-specific antigen: specificity and application to clinical practice. Brit. J. Urol.1985; 57: 50. Google Scholar 4 : Prostate-specific antigen as a serum marker for adenocarcinoma of the prostate. New Engl. J. Med.1987; 317: 909. Crossref, Medline, Google Scholar 5 : Prostate specific antigen in the diagnosis and treatment of adenocarcinoma of the prostate. II. Radical prostatectomy treated patients. J. Urol.1989; 141: 1076. Link, Google Scholar 6 : Prostate specific antigen in the diagnosis and treatment of adenocarcinoma of the prostate. I. Untreated patients. J. Urol.1989; 141: 1070. Link, Google Scholar 7 : Functionally active protein C inhibitor/plasminogen activator inhibitor-3 (PCI/PAI-3) is secreted in seminal vesicles, occurs at high concentrations in human seminal plasma and complexes with prostate-specific antigen. Thromb. Res.1991; 64: 309. Google Scholar 8 : The distribution of prostate specific antigen in men without clinical or pathological evidence of prostate cancer: relationship to gland volume and age. J. Urol.1992; 147: 837. Link, Google Scholar 9 : Origin and evolution of benign prostatic enlargement. Invest. Urol.1978; 15: 340. Medline, Google Scholar 10 : Anatomy of the prostate and morphogenesis of BPH. Prog. Clin. Biol. Res.1984; 145: 27. Google Scholar 11 : Evolving patterns of tissue composition in benign prostatic hyperplasia as a function of specimen size. Hum. Path.1990; 21: 578. Crossref, Medline, Google Scholar 12 : Early detection of residual prostate cancer after radical prostatectomy by an ultrasensitive assay for prostate specific antigen. J. Urol.1993; 149: 787. Link, Google Scholar 13 : Regulation of prostatic carcinoma cell proliferation and secretory activity by extracellular matrix and stromal secretions. Prostate1992; 21: 121. Google Scholar 14 : Clonal growth of human prostate epithelial cells is stimulated by fibroblasts. Prostate1989; 14: 251. Google Scholar 15 : Predicted prostate specific antigen results using transrectal ultrasound gland volume. Differentiation of benign prostatic hyperplasia and prostate cancer. Cancer1992; 70: 211. Google Scholar 16 : Circulating prostate-specific antigen in benign hypertrophy and localized cancer of the prostate. Can PSA be considered as a screening examination for localized cancer. Prog. Urol.1991; 1: 293. Google Scholar 17 : Comparison of PSAD and PSAT in benign and malignant prostatic disease. J. Urol.1993; 149: 414A. abstract 806. Google Scholar From the Department of Urology, Stanford University School of Medicine, Stanford, California© 1995 by American Urological Association, Inc.FiguresReferencesRelatedDetailsCited byOHIGASHI T, KANAO K, KIKUCHI E, NAKAGAWA K, NAKASHIMA J, MARUMO K and MURAI M (2018) PROSTATE SPECIFIC ANTIGEN ADJUSTED FOR TRANSITION ZONE EPITHELIAL VOLUME: THE POWERFUL PREDICTOR FOR THE DETECTION OF PROSTATE CANCER ON REPEAT BIOPSYJournal of Urology, VOL. 173, NO. 5, (1541-1545), Online publication date: 1-May-2005.KARAZANASHVILI G and ABRAHAMSSON P (2018) Prostate Specific Antigen and Human Glandular Kallikrein 2 in Early Detection of Prostate CancerJournal of Urology, VOL. 169, NO. 2, (445-457), Online publication date: 1-Feb-2003.STAMEY T and YEMOTO C (2018) EXAMINATION OF THE 3 MOLECULAR FORMS OF SERUM PROSTATE SPECIFIC ANTIGEN FOR DISTINGUISHING NEGATIVE FROM POSITIVE BIOPSY: RELATIONSHIP TO TRANSITION ZONE VOLUMEJournal of Urology, VOL. 163, NO. 1, (119-126), Online publication date: 1-Jan-2000.ZLOTTA A, DJAVAN B, PETEIN M, SUSANI M, MARBERGER M and SCHULMAN C (2018) PROSTATE SPECIFIC ANTIGEN DENSITY OF THE TRANSITION ZONE FOR PREDICTING PATHOLOGICAL STAGE OF LOCALIZED PROSTATE CANCER IN PATIENTS WITH SERUM PROSTATE SPECIFIC ANTIGEN LESS THAN 10 NG./ML.Journal of Urology, VOL. 160, NO. 6 Part 1, (2089-2095), Online publication date: 1-Dec-1998.DJAVAN B, ZLOTTA A, BYTTEBIER G, SHARIAT S, OMAR M, SCHULMAN C and MARBERGER M (2018) PROSTATE SPECIFIC ANTIGEN DENSITY OF THE TRANSITION ZONE FOR EARLY DETECTION OF PROSTATE CANCERJournal of Urology, VOL. 160, NO. 2, (411-418), Online publication date: 1-Aug-1998.LIN D, GOLD M, RANSOM S, ELLIS W and BRAWER M (2018) TRANSITION ZONE PROSTATE SPECIFIC ANTIGEN DENSITY: LACK OF USE IN PREDICTION OF PROSTATIC CARCINOMAJournal of Urology, VOL. 160, NO. 1, (77-82), Online publication date: 1-Jul-1998.Maeda H, Arai Y, Ishitoya S, Okubo K, Aoki Y and Okada T (2018) PROSTATE SPECIFIC ANTIGEN ADJUSTED FOR THE TRANSITION ZONE VOLUME AS AN INDICATOR OF PROSTATE CANCERJournal of Urology, VOL. 158, NO. 6, (2193-2196), Online publication date: 1-Dec-1997.Noldus J, Chen Z and Stamey T (2018) ISOLATION AND CHARACTERIZATION OF FREE FORM PROSTATE SPECIFIC ANTIGEN (f-PSA) IN SERA OF MEN WITH PROSTATE CANCERJournal of Urology, VOL. 158, NO. 4, (1606-1609), Online publication date: 1-Oct-1997.Marks L, Partin A, Gormley G, Dorey F, Shery E, Garris J, Subong E, Stoner E and deKernion J (2018) Prostate Tissue Composition and Response to Finasteride in Men With Symptomatic Benign Prostatic HyperplasiaJournal of Urology, VOL. 157, NO. 6, (2171-2178), Online publication date: 1-Jun-1997.Chen Z, Chen H and Stamey T (2018) Prostate Specific Antigen in Benign Prostatic Hyperplasia: Purification and CharacterizationJournal of Urology, VOL. 157, NO. 6, (2166-2170), Online publication date: 1-Jun-1997. (2018) EDITORIAL COMMENTJournal of Urology, VOL. 157, NO. 5, (1747-1747), Online publication date: 1-May-1997.Zlotta A, Djavan B, Marberger M and Schulman C (2018) Prostate Specific Antigen Density of the Transition Zone: A New Effective Parameter for Prostate Cancer PredictionJournal of Urology, VOL. 157, NO. 4, (1315-1321), Online publication date: 1-Apr-1997.Prestigiacomo A and Stamey T (2018) Can Free and Total Prostate Specific Antigen and Prostatic Volume Distinguish Between Men With Negative and Positive Systematic Ultrasound Guided Prostate Biopsies?Journal of Urology, VOL. 157, NO. 1, (189-194), Online publication date: 1-Jan-1997.Marks L, Dorey F, Rhodes T, Shery E, Rittenhouse H, Partin A and deKernion J (2018) Serum Prostate Specific Antigen Levels after Transurethral Resection of Prostate: A Longitudinal Characterization in Men with Benign Prostatic HyperplasiaJournal of Urology, VOL. 156, NO. 3, (1035-1039), Online publication date: 1-Sep-1996. (2018) EDITORIAL COMMENTJournal of Urology, VOL. 155, NO. 5, (1657-1657), Online publication date: 1-May-1996.Bangma C and Schroder F (2018) Re: Automated Prostate Volume Determination with Ultrasonographic ImagingJournal of Urology, VOL. 155, NO. 1, (292-292), Online publication date: 1-Jan-1996. Volume 153Issue 1January 1995Page: 111-114 Advertisement Copyright & Permissions© 1995 by American Urological Association, Inc.MetricsAuthor Information Peter G. Hammerer More articles by this author John E. McNeal More articles by this author Thomas A. Stamey More articles by this author Expand All Advertisement PDF downloadLoading ...
Referência(s)