Targeting DOT1L action and interactions in leukemia: the role of DOT1L in transformation and development
2010; Taylor & Francis; Volume: 14; Issue: 4 Linguagem: Inglês
10.1517/14728221003623241
ISSN1744-7631
AutoresEvan Barry, Gareth N. Corry, Theodore P. Rasmussen,
Tópico(s)Genomics and Chromatin Dynamics
ResumoImportance of the field: The establishment and maintenance of specialized chromatin is crucial for correct gene expression and chromosome stability in mammalian cells. Therefore, epigenetic insults are frequently observed in cancer. Several chromatin modifying enzymes have been implicated in leukemia, and are attractive candidates for the development of therapeutic agents.
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