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R-CHOEP-14 improves overall survival in young high-risk patients with diffuse large B-cell lymphoma compared with R-CHOP-14. A population-based investigation from the Danish Lymphoma Group

2011; Elsevier BV; Volume: 23; Issue: 1 Linguagem: Inglês

10.1093/annonc/mdr058

1569-8041

Anne Ortved Gang, Camilla Strøm, Mette Ølgod Pedersen, Francesco d’Amore, Lars Møller Pedersen, Anne Bukh, Bjarne Bach Pedersen, Michael Boe Moeller, Leif Spange Mortensen, Ole Gadeberg, Steen Ingeberg, Torben Mourits‐Andersen, Stanislaw Pulczynski, Peter de Nully Brown,

Lung Cancer Treatments and Mutations

BackgroundOptimal treatment of young patients with high-risk diffuse large B-cell lymphoma (DLBCL) remains a matter of debate and requires improvement. The combination chemotherapy with cyclophosphamide, doxorubicin, vincristine and prednisone (CHOP) with addition of etoposide (CHOEP) has in other patient groups been shown to be effective. Further improvement has been accomplished with the use of rituximab in combination with the regimens every 2 weeks (R-CHOP-14, R-CHOEP-14). The aim of the present retrospective population-based study was to compare R-CHOP-14 with R-CHOEP-14 in a cohort of high-risk patients aged 18–60 years with two or more risk factors (stage III–IV, elevated lactate dehydrogenase levels, performance status 2–4). To our knowledge, this is the first study comparing these two regimens in this patient group.MethodsWe obtained data for the period 2004–2009 from the Danish Lymphoma Database. One hundred and fifty-nine patients were eligible to enter the study. Primary end point was overall survival (OS) and secondary end points were response to treatment, progression-free survival (PFS) and safety.ResultsFour-year OS was superior in the R-CHOEP-14 group: 75% compared with 62% for R-CHOP-14 (P = 0.04). This superiority was also seen for PFS: 4-year PFS was 70% for the R-CHOEP-14 group compared with 58% for the R-CHOP-14 group (P = 0.02).ConclusionsR-CHOEP-14 is a promising regimen for young patients with high-risk DLBCL with improved OS and PFS compared with R-CHOP-14.