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European mitochondrial haplogroups are associated with CD4+ T cell recovery in HIV-infected patients on combination antiretroviral therapy

2013; Oxford University Press; Volume: 68; Issue: 10 Linguagem: Inglês

10.1093/jac/dkt206

1460-2091

María G. Guzmán, Juan Berenguer, Dariela Micheloud, Amanda Fernández‐Rodríguez, Mónica García‐Álvarez, María A. Jiménez‐Sousa, José M. Bellón, Yolanda Campos, Jaime Cosín, Teresa Aldámiz‐Echevarría, Pilar Catalán, Juan Carlos López, Salvador Resino,

HIV/AIDS drug development and treatment

There is substantial interindividual variability in the rate and extent of CD4+ T cell recovery after starting combination antiretroviral therapy (cART). The aim of our study was to determine whether mitochondrial DNA (mtDNA) haplogroups are associated with recovery of CD4+ in HIV-infected patients on cART. We carried out a retrospective study on 275 cART-naive patients with CD4+ counts <350 cells/mm3, who were followed-up during at least 24 months after initiating cART. mtDNA genotyping was performed by Sequenom's MassARRAY platform. Patients within cluster JT and haplogroup J had a lower chance of achieving a CD4+ count ≥500 cells/mm3 than patients within cluster HV and haplogroup H [hazard ratio (HR) = 0.68 (P = 0.058) and HR = 0.48 (P = 0.010), respectively]. The time of follow-up during which the CD4+ count was ≥500 cells/mm3 was longer in haplogroups HV and H than in haplogroups JT and J [20 months versus 6.2 months (P = 0.029) and 20 months versus 0 months (P = 0.024), respectively]. Additionally, haplogroups HV and H had greater chances of achieving a CD4+ count ≥500 cells/mm3 during at least 12, 36, 48 and 60 months post-cART initiation compared with patients within haplogroups JT and J. Patients within haplogroup T only had a lesser chance of achieving a CD4+ count ≥500 cells/mm3 during at least 48 months and 60 months post-cART initiation. European mitochondrial haplogroups might influence CD4+ recovery in HIV-infected patients following initiation with cART. Haplogroups J and T appear to be associated with a worse profile of CD4+ recovery, whereas haplogroup H was associated with a better CD4+ reconstitution.