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Singleton deletions throughout the genome increase risk of bipolar disorder

2008; Springer Nature; Volume: 14; Issue: 4 Linguagem: Inglês

10.1038/mp.2008.144

1476-5578

Dandan Zhang, Lijun Cheng, Yudong Qian, Ney Alliey‐Rodriguez, John R. Kelsoe, Tiffany A. Greenwood, Caroline M. Nievergelt, Thomas B. Barrett, Roger M. McKinney, Nicholas J. Schork, Erin N. Smith, Cinnamon S. Bloss, John I. Nürnberger, Howard J. Edenberg, Tatiana Foroud, W Sheftner, William Lawson, Evaristus A. Nwulia, Márcio Hipólito, William Coryell, John Rice, William Byerley, Francis J. McMahon, T G Schulze, Wade H. Berrettini, James B. Potash, Pamela L. Belmonte, Peter P. Zandi, M. G. McInnis, Sebastian Zöllner, David Craig, Szabocls Szelinger, Daphne Koller, Susan L. Christian, Chunyu Liu, Elliot S. Gershon,

Genetic Associations and Epidemiology

An overall burden of rare structural genomic variants has not been reported in bipolar disorder (BD), although there have been reports of cases with microduplication and microdeletion. Here, we present a genome-wide copy number variant (CNV) survey of 1001 cases and 1034 controls using the Affymetrix single nucleotide polymorphism (SNP) 6.0 SNP and CNV platform. Singleton deletions (deletions that appear only once in the dataset) more than 100 kb in length are present in 16.2% of BD cases in contrast to 12.3% of controls (permutation P=0.007). This effect was more pronounced for age at onset of mania ⩽18 years old. Our results strongly suggest that BD can result from the effects of multiple rare structural variants.