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Multiple phenotypic consequences of the Ig/Myc translocation in B‐cell‐derived tumors

1989; Wiley; Volume: 1; Issue: 1 Linguagem: Inglês

10.1002/gcc.2870010103

1098-2264

George Klein,

CAR-T cell therapy research

Genes, Chromosomes and CancerVolume 1, Issue 1 p. 3-8 Review Article Multiple phenotypic consequences of the Ig/Myc translocation in B-cell-derived tumors Dr. George Klein, Corresponding Author Dr. George Klein Department of Tumor Biology, Karolinska Institute, Stockholm, SwedenDept. of Tumor Biology, Karolinska Institute, Box 60400, S-104 01 Stockholm, SwedenSearch for more papers by this author Dr. George Klein, Corresponding Author Dr. George Klein Department of Tumor Biology, Karolinska Institute, Stockholm, SwedenDept. of Tumor Biology, Karolinska Institute, Box 60400, S-104 01 Stockholm, SwedenSearch for more papers by this author First published: September 1989 https://doi.org/10.1002/gcc.2870010103Citations: 40AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onEmailFacebookTwitterLinkedInRedditWechat References Adams JM, Harris AW, Pinkert CA, Corcoran LM, Alexander WS, Cory S, Palmiter RD, Brinster RL (1985) The c-myc oncogene driven by immunoglobulin enhancers induces lymphoid malignancy in transgenic mice. Nature 318: 533–538. Alt FW, Blackwell TK, De Pinho RA Reth MG, Yancopoulos GD (1986) Regulation of genome rearrangement events during lymphocyte differentiation. Immunol Rev 89: 5–30. Altiok E, Klein G, Zech L, Uno M, Ehlin-Henriksson B, Battat S Ono Y, Ernberg I (1989) EBV-transformed pro-B cells are prone to illegitimate recombination between the Su region and other chromosomes. Proc Natl Acad Sci USA (in press). Avila-Carino J, Torsteinsdottir S, Bejarano MT, Klein G Klein E, Masucci MG (1988) Combined treatment with interferon (IFN)-γ and tumor necrosis factor (TNF)-α up-regulates the expression of HLA class I determinants in Burkitt lymphoma lines. Cell Immunol 117: 303–311. Claesson M, Henriksson M, Sumegi J, Klein G, Hammarskjöld M-L (1987) Elevated c-myc expression facilitates the replication of SV 40 DNA in human lymphoma cells. Nature 330: 272–274. Coppola JA, Cole MD (1986) Constitutive c-myc oncogene expression blocks mouse erythroleukaemia cell differentiation but not commitment. Nature 320: 760–763. Cory S (1986) Activation of cellular oncogenes in hemopoietic cells by chromosome translocation. Adv Cancer Res 47: 189–234. Dmitrovsky E, Kuehl WM, Hollis GF, Kirsch IR, Bender TP, Segal S (1986) Expression of a transfected human c-myc oncogene inhibits differentiation of a mouse erythroleukaemia cell line. Nature 322: 748–750. Ehlin-Henriksson B, Manneborg-Sandlund A, Klein G (1987) Expression of B-cell specific markers in different Burkitt lymphoma subgroups. Int J Cancer 39: 211–218. Emberg I, Falk K, Minarovits J, Busson P, Tursz T, Masucci MG, Klein G (1989) The role of methylation in the phenotype dependent modulation of EBNA 2 and LMP genes in latently EBV infected cells. J Gen Virol (in press). Gordon J, Guy G, Walker L (1985) Autocrine models of B-lymphocyte growth. I. Role of cell contact and soluble factors in T-independent B-cell responses. Immunology 56: 329–335. Gratama JW, Oosterveer MAP, Zwaan FE, Lepoutre J, Klein G, Emberg I (1988) Eradication of Epstein-Barr virus by allogeneic bone marrow transplantation: Implications for sites of viral latency. Proc Natl Acad Sci USA 85: 8693–8696. Gregory CD, Murray RJ, Edwards CF, Rickinson AB (1988) Down-regulation of cell adhesion molecules LFA-3 and ICAM-1 in Epstein-Barr virus-positive Burkitt's lymphoma underlies tumor cell escape from virus-specific T cell surveillance. J Exp Med 167: 1811–1824. Gregory CD, Tursz T, Edwards CF, Tetaud C, Talbot M, Caillou B Rickinson AB, Lipinski M (1987) Identification of a subset of normal B cells with a Burkitt's lymphoma (BL)-like phenotype. J Immunol 139: 313–318. Hayward WS, Neel BG, Astrin SM (1981) Activation of a cellular onc gene by promoter insertion in ALV-induced lymphoid leukosis. Nature 290: 475–480. Katamine S, Otsu M, Tada K, Tsuchiya S, Sato T, Ishida N, Honjo T, Ono Y (1984) Epstein-Barr virus transforms precursor B-cells even before immunoglobulin gene rearrangements. Nature 309: 369–372. Klein G (1989) Viral latency and transformation: The strategy of Epstein-Barr virus. Cell (in press). Klein G, Klein E (1985) Myc/Ig juxtaposition by chromosomal translocations: Some new insights, puzzles and paradoxes. Immunol Today 6: 208–215. Larsson L-G, Ivhed I, Gidlund M, Pettersson U, Vennström B, Nilsson K (1988) Phorbol ester-induced terminal differentiation is inhibited in human U-937 monoblastic cells expressing a v-myc oncogene. Proc Natl Acad Sci USA 85: 2638–2642. Lewin N, Åman P, Masucci MG, Klein E, Klein G, Oberg B, Strander H Henle W, Henle G (1987) Characterization of EBV-carrying B-cell populations in healthy seropositive individuals with regard to density, release of transforming virus and spontaneous outgrowth. Int J Cancer 39: 472–476. Magrath I (1989) The pathogenesis of Burkitt's lymphoma. Adv Cancer Res (in press). Masucci MG, Contreras-Salazar B, Ragnar E, Falk K, Minarovits J Ernberg I, Klein G (1989a) 5-Azacytidine up-regulates the expression of EBNA 2–6 and LMP in an EBNA-1 positive. EBNA 2–6 and LMP negative Burkitt lymphoma line. J Virol 63: 3135–3141. Masucci MG, Stam NJ, Torsteinsdottir S, Neefjes JJ Klein G, Ploegh HJ (1989b) Allele specific down-regulation of MHC Class I antigens in Burkitt lymphoma lines. Cell Immunol 1220: 396–400. Masucci MG, Torsteinsdottir S, Colombani J, Brautbar C, Klein E, Klein G (1987) Down-regulation of C1 I HLA antigens and of the Epstein-Barr virus-encoded latent membrane protein in Burkitt lymphoma lines. Proc Natl Acad Sci USA 84: 4567–4571. Nilsson K (1978) INSERM Symposium No. 8: Human Lymphocyte Differentiation in Its Application to Cancer. B Seru, C Rosenfeld (eds): Amsterdam: Elsevier/North Holland Biomedical Press, pp 307–317. Otsu M, Katamine S, Uno M, Yamaki M, Ono Y, Klein G, Sasaki MS Yaoita Y, Honjo T (1987) Molecular characterization of novel reciprocal translocation t(6;14) in an Epstein-Barr virus-transformed B-cell precursor. Mol Cell Biol 7: 708–717. Pear WS, Nelson SF, Axelsson H, Wahlström G, Bazin H Klein G, Sumegi J (1988a) Aberrant class switching juxtaposes c-myc with a middle repetitive element (line) and an IgH intron in two spontaneously arising rat immunocytomas. Oncogene 2: 499–507. Pear WS, Wahlström G, Nelson SF, Axelsson H, Szeles A, Wiener F, Bazin H Klein G, Sumegi J (1988b) 6;7 Chromosomal translocation in spontaneously arising rat immunocytomas: evidence for c-myc breakpoint clustering and correlation between isotypic expression and the c-myc target. Mol Cell Biol 8: 441–451. Potter M, Mushinski JF, Mushinski EB, Brust S, Wax JS, Wiener F, Babonits M Rapp UR, Morse IHC (1987) Avian v-myc replaces chromosomal translocation in murine plasmacytomagenesis. Science 235: 787–789. Prochownik EV, Kukowska J (1986) Deregulated expression of c-myc by murine erythroleukemia cells prevents differentiation. Nature 322: 848–850. Rickinson AB (1987) Cellular immunological responses to the virus infection. In MA Epstein, BG Achong (eds): The Epstein-Barr Virus: Recent Advances. London: William Heinemann Medical Books, pp 75–125. Rooney CM, Gregory CD, Rowe M, Finerty S, Edwards C, Rupani H, Rickinson AB (1986) Endemic Burkitt's lymphoma: phenotypic analysis of tumor biopsy cells and of derived tumor cell lines. JNCI 77: 681–687. Rooney CM, Rickinson AB, Moss DJ, Lenoir GM, Epstein MA (1984) Paired Epstein-Barr virus-carrying lymphoma and lymphoblastoid cell lines from Burkitt's lymphoma patients: comparative sensitivity to non-specific and to allo-specific cytotoxic responses in vitro. Int J Cancer 34: 339–348. Rowe M, Rowe DT, Gregory CD, Young LS, Farrell PJ, Rupani H, Rickinson AB (1987) Differences in B cell growth phenotype reflect novel patterns of Epstein-Barr virus latent gene expression in Burkitt's lymphoma cells. EMBO J 6: 2743–2751. Sakthivel R, Christensson B, Ehlin-Henriksson B, Klein G (1989) Immunophenotypic characterization of follicle center cell derived non-Hodgkin's lymphoma. Int J Cancer 43: 624–630. Torsteinsdottir S, Andersson ML, Avila-Carino J, Ehlin-Henriksson B, Masucci MG Klein G, Klein E (1989) Reversion of tumorigenicity and decreased agarose clonability after EBV conversion of an IgH/myc translocation carrying BL line. Int J Cancer 43: 273–278. Torsteinsdottir S, Brautbar C, Klein G, Klein E, Masucci MG (1988) Differential expression of HLA antigens on human B-cell lines of normal and malignant origin: a consequence of immune surveillance or a phenotypic vestige of the progenitor cells?. Int J Cancer 41: 913–919. Citing Literature Volume1, Issue1September 1989Pages 3-8 ReferencesRelatedInformation