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Primary antiphospholipid syndrome: a low-grade auto-inflammatory disease?

2008; Oxford University Press; Volume: 47; Issue: 12 Linguagem: Inglês

10.1093/rheumatology/ken382

1462-0332

Paul R. J. Ames, Iolanda Antinolfi, Antonio Ciampa, Joana R. Batuca, Giovanna Scenna, Luis R. Lopez, José Delgado Alves, L. Iannaccone, Eiji Matsuura,

Renal Diseases and Glomerulopathies

Objective. To test the inflammation and immune activation hypothesis in primary thrombotic APS (PAPS) and to identify clinical and laboratory factors related to inflammation and immune activation. Methods. PAPS (n = 41) patients were compared with patients with inherited thrombophilia (IT, n = 44) and controls (CTR, n = 39). IgG aCL, IgG anti-β2-glycoprotein I (β2GPI), high-sensitivity CRP (hs-CRP), serum amyloid A (SAA), CRP bound to oxidized low-density lipoprotein–β2GPI complex (CRP–oxLDL–β2GPI) (as inflammatory markers) neopterin (NPT), soluble CD14 (sCD14) (as immune activation markers) were measured by ELISA. Results. After correction for confounders, PAPS showed higher plasma levels of hs-CRP (P = 0.0004), SAA (P < 0.01), CRP–oxLDL–β2GPI (P = 0.0004), NPT (P < 0.0001) and sCD14 (P = 0.007) than IT and CTR. Two regression models were applied to the PAPS group: in the first, IgG aCL and IgG β2GPI were included amongst the independent variables and in the second they were excluded. In the first model, SAA (as the dependent variable) independently related to thrombosis number (P = 0.003); NPT (as the dependent variable) independently related to thrombosis type (arterial, P = 0.03) and number (P = 0.04); sCD14 (as the dependent variable) independently related to IgG β2GPI (P = 0.0001), age (0.001) and arterial thrombosis (P = 0.01); CRP–oxLDL–β2GPI (as the dependent variable) independently related to IgG β2GPI (P = 0.0001). In the second model, sCD14 and NPT independently related to each other (P = 0.002) (this was noted also in the IT group, P < 0.0001) and CRP–oxLDL–β2GPI independently predicted SAA (P = 0.002). Conclusion. Low-grade inflammation and immune activation occur in thrombotic PAPS and relate to clinical features and aPL levels.