Portal de Periódicos da CAPES

Rapid evolving RNA gene HAR1A and schizophrenia

2007; Elsevier BV; Volume: 99; Issue: 1-3 Linguagem: Inglês

10.1016/j.schres.2007.10.011

1573-2509

A. Tolosa-Delgado, Julio Sanjuán, C. Leal, Javier Costas, María Dolores Moltó, R. de Frutos,

RNA regulation and disease

Long non-coding RNAs (lncRNAs) participate in the neurodevelopment and species divergence. They also contribute in the etiology of neuropsychiatric disorders. The highly accelerated region 1a (HAR1A) lncRNA is regarded as one of the features of the evolutionary deviation of humans and chimpanzees and participates in specification and migration of neuron especially in cortex. In the current study, we genotyped a single nucleotide polymorphism (SNP) in this lncRNA (rs750697) in a population of Iranian patients with different neuropsychiatric conditions such as substance addiction, attention deficit hyperactive disorder, bipolar disorder, major depressive disorder and schizophrenia. There was no significant difference between allele and genotype frequencies of this SNP between any subgroup of patients and the corresponding age- and sex-matched controls. Consequently, the current study excludes the participation of the rs750697 SNP in the etiology of neuropsychiatric disorders in Iranian population. Further assessment of other SNPs within this lncRNA might lead to identification of possible risk factors for neuropsychiatric disorders.