Circulating Growth Differentiation Factor 11/8 Levels Decline With Age
2015; Lippincott Williams & Wilkins; Volume: 118; Issue: 1 Linguagem: Inglês
10.1161/circresaha.115.307521
ISSN1524-4571
AutoresTommaso Poggioli, Ana Vujić, Peiguo Yang, Claudio Macias-Treviño, Aysu Uygur, Francesco S. Loffredo, James R. Pancoast, Miook Cho, Jill M. Goldstein, Rachel M. Tandias, E Torrado González, Ryan G. Walker, Thomas B. Thompson, Amy J. Wagers, Yick W. Fong, Richard Lee,
Tópico(s)Nutrition and Health in Aging
ResumoGrowth differentiation factor 11 (GDF11) and GDF8 are members of the transforming growth factor-β superfamily sharing 89% protein sequence homology. We have previously shown that circulating GDF11 levels decrease with age in mice. However, a recent study by Egerman et al reported that GDF11/8 levels increase with age in mouse serum.
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