Produção Nacional
Revisado por pares
Is there a relationship between lipids metabolism and splenic surgeries?
2012; Sociedade Brasileira Para o Desenvolvimento da Pesquisa em Cirurgia; Volume: 27; Issue: 11 Linguagem: Inglês
10.1590/s0102-86502012001100002
ISSN1678-2674
AutoresLuiz Ronaldo Alberti, Denny Fabrício Magalhães Veloso, Leonardo de Souza Vasconcellos, Andy Petroianu,
Tópico(s)Cancer, Lipids, and Metabolism
ResumoTo assess the influence of spleen surgeries (splenectomy, presence of spleen and after conservative surgeries) on lipids metabolism.Fifty female Wistar rats of similar weight and age were divided into five groups submitted to the following procedures: Group 1 - control, with an intact spleen; Group 2 - sham operation, Group 3 - total splenectomy; Group 4 - subtotal splenectomy, and Group 5 - total splenectomy complemented with autogenous spleen tissue implants. Four months after the interventions, serum triglycerides, total cholesterol and fractions (VLDL-cholesterol, LDL-cholesterol, HDL-cholesterol) were determined. The results for the four groups were compared by analysis of variance followed by the Tukey-Kramer test, with the level of significance set at p<0.05.There were no differences between groups 1, 2, 4 and 5. In the animals submitted to total splenectomy, total cholesterol (p=0.0151) and LDL-cholesterol fraction concentrations (p<0.0001) were higher, whereas HDL-cholesterol fraction concentrations were lower (p=0.0026) than those detected in the other groups. There was no difference in triglycerides (p=0.1571) or VLDL-cholesterol (p=0.2527) between groups.Splenectomy is related to changes in the lipid metabolism that are reverted by autogenous spleen tissue implants.
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