Preparation and reactions of 2′- and 3′-vinyl bromides of uracil-nucleosides: versatile synthons for anti-hiv agents
1991; Elsevier BV; Volume: 32; Issue: 28 Linguagem: Inglês
10.1016/s0040-4039(00)92715-1
ISSN1873-3581
AutoresKazuhiro Haraguchi, Yoshiharu Itoh, Hiromichi Tanaka, Tadashi Miyasaka,
Tópico(s)Pneumocystis jirovecii pneumonia detection and treatment
ResumoBromination and successive oxidation of 1-[5-O-(t-butyldiphenyl-silyl)-3-deoxy-3-phenylseleno-β-D-xylofuranosyl]uracil yields the 2′- and 3′-vinyl bromides, which serve as synthons for 2′- or 3′-substituted 2′,3′-dide-hydro 2′,3′ -dideoxyuridines via palladium-catalyzed cross-coupling or the halogen lithium exchange reaction.
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