Synthesis of a divalent glycoside of an α-galactosyl disaccharide epitope involved in the hyperacute rejection of xenotransplantation
2001; Elsevier BV; Volume: 334; Issue: 4 Linguagem: Inglês
10.1016/s0008-6215(01)00194-x
ISSN1873-426X
AutoresYi-Pin Lu, Hui Li, Meng‐Shen Cai, Zhongjun Li,
Tópico(s)Amino Acid Enzymes and Metabolism
Resumo3,6-dioxaoct-1,8-diyl di-(3-O-alpha-D-galactopyranosyl-beta-D-galactopyranoside) was synthesized for use in research on hyperacute rejection of xenotransplantation. The trichloroacetate method was successfully applied to form stereoselectively the alpha-D-galactosyl linkage under mild reaction conditions and a simple procedure. The divalent O-glycoside was formed from the corresponding trichloroacetimidate in one step with reasonable yield.
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