Artigo Acesso aberto Revisado por pares

Increased Pulmonary Pressures and Myocardial Wall Stress in Children with Severe Malaria

2010; Oxford University Press; Volume: 202; Issue: 5 Linguagem: Inglês

10.1086/655225

ISSN

1537-6613

Autores

Jacqueline Janka, Ousmane Koita, Broulaye Traoré, Josépha M. Traoré, Fawaz Mzayek, Vandana Sachdev, Xunde Wang, K Sanogo, Lansana Sangaré, Laurel Mendelsohn, Henry Masur, Gregory J. Kato, Mark T. Gladwin, Donald J. Krogstad,

Tópico(s)

Liver Disease Diagnosis and Treatment

Resumo

Chronic intravascular hemolysis leads to nitric oxide (NO) depletion and pulmonary hypertension in sickle cell disease. To test whether this pathophysiology occurs in malaria, we examined in Mali 53 children who were admitted to the hospital with severe malaria (excluding cerebral malaria) and 31 age-matched controls.

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