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BIBTEX RIS

Mitochondrial haplogroups associated with end-stage heart failure and coronary allograft vasculopathy in heart transplant patients

2011; Oxford University Press; Volume: 33; Issue: 3 Linguagem: Inglês

10.1093/eurheartj/ehr280

ISSN

1522-9645

Autores

M. Esther Gallardo, Pablo García‐Pavía, Rodrigo Chamorro, María Eugenia Vázquez, Manuel Gómez‐Bueno, I. Millán, Berta Almoguera, V. Domingo, Javier Segovia, Carlos Vilches, Luis Alonso-Pulpón, Rafael Garesse, Belén Bornstein,

Tópico(s)

Organ Transplantation Techniques and Outcomes

Resumo

AimsMitochondrial haplogroups are known to influence individual predisposition to a wide spectrum of metabolic and degenerative diseases, including ischaemic cardiovascular diseases. We have examined the influence of the mitochondrial DNA (mtDNA) background on the development of human end-stage heart failure (HF) in patients undergoing heart transplantation. The influence of mtDNA haplogroups on the incidence of transplant-related complications, mainly cardiac allograft vasculopathy (CAV), and on post-transplant survival was also studied.

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