The Guanine Nucleotide-Binding Switch in Three Dimensions
2001; American Association for the Advancement of Science; Volume: 294; Issue: 5545 Linguagem: Inglês
10.1126/science.1062023
ISSN1095-9203
AutoresIngrid R. Vetter, Alfred Wittinghofer,
Tópico(s)Calcium signaling and nucleotide metabolism
ResumoGuanine nucleotide–binding proteins regulate a variety of processes, including sensual perception, protein synthesis, various transport processes, and cell growth and differentiation. They act as molecular switches and timers that cycle between inactive guanosine diphosphate (GDP)–bound and active guanosine triphosphate (GTP)–bound states. Recent structural studies show that the switch apparatus itself is a conserved fundamental module but that its regulators and effectors are quite diverse in their structures and modes of interaction. Here we will try to define some underlying principles.
Referência(s)