MYRbase: analysis of genome-wide glycine myristoylation enlarges the functional spectrum of eukaryotic myristoylated proteins
2004; BioMed Central; Volume: 5; Issue: 3 Linguagem: Inglês
10.1186/gb-2004-5-3-r21
ISSN1474-760X
AutoresSebastian Maurer‐Stroh, Masaki Gouda, Maria Novatchkova, Alexander Schleiffer, Georg Schneider, Fernanda L. Sirota, Michael Wildpaner, Nobuhiro Hayashi, Frank Eisenhaber,
Tópico(s)Alzheimer's disease research and treatments
ResumoWe evaluated the evolutionary conservation of glycine myristoylation within eukaryotic sequences. Our large-scale cross-genome analyses, available as MYRbase, show that the functional spectrum of myristoylated proteins is currently largely underestimated. We give experimental evidence for in vitro myristoylation of selected predictions. Furthermore, we classify five membrane-attachment factors that occur most frequently in combination with, or even replacing, myristoyl anchors, as some protein family examples show.
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