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The mechanical properties of two forms of primidone predicted from their crystal structures

1996; Elsevier BV; Volume: 145; Issue: 1-2 Linguagem: Inglês

10.1016/s0378-5173(96)04760-6

1873-3476

Robin Payne,

Crystallization and Solubility Studies

Molecular modelling is used to predict the mechanical properties of aspirin and forms A and B of primidone. It is shown that the predictive method gives values which are in good agreement with the experimental ones. The method is therefore of great potential value to those interested in the compaction characteristics of pharmaceutically active compounds, as it obviates the need for measurements which can be difficult to make.