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Low preoperative plasma cholinesterase activity as a risk marker of postoperative delirium in elderly patients

2011; Oxford University Press; Volume: 40; Issue: 5 Linguagem: Inglês

10.1093/ageing/afr053

1468-2834

Joaquim Cerejeira, Pedro Batista, V. Nogueira, Horácio Firmino, Adriano Vaz‐Serra, Elizabeta B. Mukaetova‐Ladinska,

Cholinesterase and Neurodegenerative Diseases

Background: delirium is a frequent neuropsychiatric syndrome affecting medical and surgical elderly patients. Cholinergic dysfunction has been implicated in delirium pathophysiology and plasmatic acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE) activities are suppressed in patients with delirium. In this cohort study, we investigated whether these changes emerge during delirium or whether they are present before its onset.