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Physicochemical Properties of Protein‐Coated Gold Nanoparticles in Biological Fluids and Cells before and after Proteolytic Digestion

2013; Wiley; Volume: 52; Issue: 15 Linguagem: Inglês

10.1002/anie.201208019

1521-3773

Munish Chanana, Pilar Rivera Gil, Miguel A. Correa‐Duarte, Luis M. Liz‐Marzán, Wolfgang J. Parak,

Polymer Surface Interaction Studies

What's going on in there?! Little is known about the fate of nanoparticles (NPs) after their internalization by cells and organisms. Protein-coated gold NPs were used to study the physicochemical properties of NPs in extra- and intracellular fluids. These potential vehicles for enzymatic drug delivery were highly stable at pH 7.4 in the presence of salts and free proteins, but agglomerated reversibly under acidic conditions (see picture). As a service to our authors and readers, this journal provides supporting information supplied by the authors. Such materials are peer reviewed and may be re-organized for online delivery, but are not copy-edited or typeset. Technical support issues arising from supporting information (other than missing files) should be addressed to the authors. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.