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Unusual E ‐Selective Ring‐Closing Metathesis To Form Eight‐Membered Rings

2010; Wiley; Volume: 49; Issue: 52 Linguagem: Inglês

10.1002/anie.201004746

1521-3773

Ryosuke Matsui, Kentaro Seto, Kazuhiro Fujita, Takahiro Suzuki, Atsuo Nakazaki, Susumu Kobayashi,

Model-Driven Software Engineering Techniques

Tied back: The title reaction was observed when a silicon-tethered diene was treated with the Hoveyda–Grubbs second-generation catalyst. The structural requirements for the E-olefin-forming ring-closing metathesis, and the transition state leading to E olefin are discussed. This methodology will be useful in the synthesis of polyketides containing a pent-2-ene-1,5-diol unit.