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Solid‐Phase Synthesis of Sequence‐Defined T‐, i‐, and U‐Shape Polymers for pDNA and siRNA Delivery

2011; Wiley; Volume: 50; Issue: 38 Linguagem: Inglês

10.1002/anie.201102165

1521-3773

David Schaffert, Christina Troiber, Eveline E. Salcher, Thomas Fröhlich, Irene Martín, Naresh Badgujar, Christian Dohmen, Daniel Edinger, Raphaela Kläger, Gelja Maiwald, Katarina Farkasova, Silke Seeber, Kerstin Jahn‐Hofmann, Philipp Hadwiger, Ernst Wagner,

DNA and Nucleic Acid Chemistry

Artificial oligo(ethylene amino) acids, together with selected natural amino acids and fatty acid modifications, have been used for the solid-phase-assisted synthesis of polymers with precise sequence, topology, and modifications (see picture). First proof-of-concept studies demonstrate the high potential of such polymers in pDNA and siRNA delivery. K=lysine, A=alanine. Detailed facts of importance to specialist readers are published as "Supporting Information". Such documents are peer-reviewed, but not copy-edited or typeset. They are made available as submitted by the authors. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.