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ATP, Creatine Phosphate and Glycogen Content in Human Myocardial Biopsies: Markers for the Efficacy of Cardioprotection During Aorto-Coronary Bypass Surgery

1984; SAGE Publishing; Volume: 18; Issue: 3 Linguagem: Inglês

10.1177/153857448401800301

0042-2835

Ger J. Vusse, Will A. Coumans, Erik van der Veen, A J Drake, Willem Flameng, Raf Suy,

Cardiac Imaging and Diagnostics

Measurements of the myocardial content of ATP, creatine phosphate and glycogen provide a sensitive marker of the effect of inevitably global ischemia on myocardial tissue during aorto-coronary bypass surgery and give insight in the efficacy of various cardioprotective techniques. Continuous aortic cross clamping for performance of the distal anastomoses with multidose St. Thomas cardioplegia did not result in significant changes in the myocardial ATP, creatine phosphate and glycogen content. In contrast, hypothermic intermittent crossclamping resulted in a significant reduced tissue content of these markers of myocardial ischemia.