Haemoglobin gene frequencies in the Jamaican population: a study in 100,000 newborns
1986; Wiley; Volume: 64; Issue: 2 Linguagem: Inglês
10.1111/j.1365-2141.1986.tb04117.x
ISSN1365-2141
AutoresG. R. Serjeant, B. E. Serjeant, M. Forbes, Richard Hayes, Douglas R. Higgs, H. Lehmann,
Tópico(s)Neonatal Health and Biochemistry
ResumoS ummary . The gene frequencies of abnormal haemoglobins have been determined in a group of 100 000 Jamaican newborns screened over a period of 8½ years. The population is predominantly of West African origin and the survey represents approximately one quarter of all island deliveries within the period of the study. The common β globin chain abnormalities β S and β c occurred with gene frequencies of 0.055 and 0.019 respectively; β thalassaemia was relatively rare. In contrast, α thalassaemia was quite common, occurring with a gene frequency of 0.183. In addition to these common abnormalities, the frequencies of 256 rare abnormal haemoglobins are described. This survey thus represents a complete and accurate documentation of the α and β globin variants that occur in the Jamaican population.
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