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Concordance Between 11 C-PIB-PET and Clinical Diagnosis in a Memory Clinic

2015; SAGE Publishing; Volume: 30; Issue: 6 Linguagem: Inglês

10.1177/1533317515576387

1938-2731

Chrem Mendez Patricio, Gabriela Cohen, Russo Maria Julieta, Fernandez Suarez Marcos, Nahas Federico, Griselda Russo, Wierszylo Claudio, Paz Santiago, Tabaschi Leonardo, Campos Jorge, Amengual Alejandra, Kremer Janus, Guinjoan Salvador, R. Leiguarda, Sevlever Gustavo, Silvia Vázquez, Allegri Ricardo,

Functional Brain Connectivity Studies

Introduction: Today, ligands that bind to fibrillar β-amyloid are detectable by Positron Emission Tomography (PET) allowing for in vivo visualization for Abeta burden. However, amyloid plaques detection per se does not establish Alzheimer’s Disease diagnosis. In this sense, the utility of amyloid imaging to improve clinical diagnosis was settled only for specific clinical scenarios and few studies have assessed amyloid molecular neuroimaging in a broader clinical setting. The aim of this study is to determine the frequency of PiB amyloid findings in different diagnostic syndromes grouped into high and low probability pre- test categories, taking into account pre-test clinical assumption of the presence of AD related pathology. Methods: 144 patients were assigned into categories of high or low pretest probability according to clinical suspicion of AD pathology. The high probability group included: amnestic Mild Cognitive Impairment (MCI), amnestic and other domains MCI, Dementia of Alzheimer’s Type (DAT), Posterior Cortical Atrophy (PCA), logopenic Primary Progressive Aphasia (PPA), Cerebral Amyloid Angiopathy and mixed dementia. The low assumption group included: normal controls, non-amnestic MCI, non-logopenic PPA and Frontotemporal Dementia (FTD). Results: Only normal controls and DAT patients (typical and atypical presentation) were the most consistent across clinical and molecular diagnostics. MCI, non-logopenic PPA and FTD were the syndromic diagnoses that most discrepancies were found. Discussion: This study demonstrates that detecting in vivo amyloid plaques by molecular imaging is considerably frequent in most of the dementia syndromes and shows that there are frequent discordance between molecular diagnosis and clinical assumption.