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Organophosphorus Flame Retardants Inhibit Specific Liver Carboxylesterases and Cause Serum Hypertriglyceridemia

2014; American Chemical Society; Volume: 9; Issue: 5 Linguagem: Inglês

10.1021/cb500014r

1554-8937

Patrick J. Morris, Daniel Medina-Cleghorn, Ann Heslin, Sarah M. King, Joseph Orr, Melinda M. Mulvihill, Ronald M. Krauss, Daniel K. Nomura,

Pesticide and Herbicide Environmental Studies

Humans are prevalently exposed to organophosphorus flame retardants (OPFRs) contained in consumer products and electronics, though their toxicological effects and mechanisms remain poorly understood. We show here that OPFRs inhibit specific liver carboxylesterases (Ces) and cause altered hepatic lipid metabolism. Ablation of the OPFR target Ces1g has been previously linked to dyslipidemia in mice. Consistent with OPFR inhibition of Ces1g, we also observe OPFR-induced serum hypertriglyceridemia in mice. Our findings suggest novel toxicities that may arise from OPFR exposure and highlight the utility of chemoproteomic and metabolomic platforms in the toxicological characterization of environmental chemicals.