Produção Nacional
Revisado por pares
Effect of thiazolidine LPSF SF29 on the growth and morphology of Trypanosoma cruzi
2012; Elsevier BV; Volume: 41; Issue: 2 Linguagem: Inglês
10.1016/j.ijantimicag.2012.09.018
ISSN1872-7913
AutoresThiago Moreira, Artur Felipe Santos Barbosa, Phercyles Veiga-Santos, Cristina Henriques, Andrea Henriques‐Pons, Suely Lins Galdino, Maria do Carmo Alves de Lima, Ivan da Rocha Pitta, Wanderley de Souza, Técia Maria Ulisses de Carvalho,
Tópico(s)Lysosomal Storage Disorders Research
ResumoChagas disease, caused by the protozoan Trypanosoma cruzi, is an endemic illness in Latin America. Efforts have been made by several groups to develop new effective and safe anti-T. cruzi drugs. In the present work, we show that thiazolidine LPSF SF29 inhibited growth of the epimastigote and amastigote forms and caused lysis in the trypomastigote form of T. cruzi, leading to death of the protozoan. Mitochondrial dysfunction was also observed. The thiazolidine induced ultrastructural alterations such as detachment of the flagellar membrane, intense mitochondrial swelling, formation of myelin-like figures and the appearance of autophagosomes. Taken together, these results suggest that this new thiazolidine is active against T. cruzi and constitutes a promising drug for the therapy of Chagas disease.
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