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HMG-CoA reductase inhibitor attenuates experimental autoimmune myocarditis through inhibition of T cell activation

2004; Oxford University Press; Volume: 64; Issue: 3 Linguagem: Inglês

10.1016/j.cardiores.2004.09.014

1755-3245

Ryoko Wakizono Azuma, Jun Suzuki, Masahiro Ogawa, Hideki Futamatsu, Noritaka Koga, Yasuyuki Onai, Hisanori Kosuge, M. Isobe,

Inflammasome and immune disorders

Objective: This study tested the hypothesis that 3-hydroxy-3-methyl-glutaryl coenzyme A (HMG-CoA) reductase inhibitor affects T cell-mediated autoimmunity through inhibition of nuclear factor-κB (NFκB) and reduces the severity of experimental autoimmune myocarditis (EAM).