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Sophistication of foldamer form and function in vitro and in vivo

2007; Elsevier BV; Volume: 11; Issue: 6 Linguagem: Inglês

10.1016/j.cbpa.2007.09.009

1879-0402

Arjel D. Bautista, Cody J. Craig, Elizabeth A. Harker, Alanna Schepartz,

Advanced biosensing and bioanalysis techniques

Advances in the foldamer field in recent years are as diverse as the backbones of which they are composed. Applications have ranged from cellular penetration and membrane disruption to discrete molecular recognition, while efforts to control the complex geometric shape of foldamers has entered the realm of tertiary and quaternary structure. This review will provide recent examples of progress in the foldamer field, highlighting the significance of this class of compounds and the advances that have been made towards exploiting their full potential.