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Involvement of monoamine oxidase B on models of postoperative and neuropathic pain in mice

2012; Elsevier BV; Volume: 690; Issue: 1-3 Linguagem: Inglês

10.1016/j.ejphar.2012.06.042

1879-0712

Jardel Gomes Villarinho, Sara Marchesan Oliveira, Cássia Regina Silva, Thaíssa Nunes Cabreira, Juliano Ferreira,

Botulinum Toxin and Related Neurological Disorders

In this study we assessed the involvement of monoamine oxidase B (MAO-B), a key enzyme implicated in monoamine metabolism, on postoperative (plantar incision) and neuropathic (partial sciatic nerve ligation) pain models in mice. Paw incision submitted mice showed a significant decrease in mechanical threshold compared with the sham-operated mice, characterizing the development of mechanical allodynia. The selective and irreversible MAO-B inhibitor selegiline, at a dose sufficient to selectively inhibit MAO-B activity (10 mg/kg), showed an anti-allodynic effect from 0.5 to 6 h after incision. Likewise, partial sciatic nerve ligation submitted mice also developed mechanical allodynia, which was reversed by selegiline (10 mg/kg) from 2 to 6 h after treatment. In addition, a significant increase on striatal MAO-B activity was observed in neuropathic mice compared with the sham-operated animals, which was reversed by selegiline treatment. Taken together, our results showed that MAO-B seems to exert a critical role in the development of postoperative and neuropathic pain.