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Stroke in first‐degree relatives of patients with cervical artery dissection

2014; Wiley; Volume: 21; Issue: 8 Linguagem: Inglês

10.1111/ene.12437

1468-1331

M. Kloss, Caspar Grond‐Ginsbach, Alessandro Pezzini, Tiina M. Metso, Antti J. Metso, Stéphanie Debette, Didier Leys, Jean Dallongeville, Valeria Caso, Vincent Thijs, Anna Bersano, Emmanuel Touzé, Leo H. Bonati, Turgut Tatlisumak, Marcel Arnold, Philippe Lyrer, Stefan T. Engelter,

Moyamoya disease diagnosis and treatment

Background and purpose Patients with ischaemic stroke ( IS ) caused by a spontaneous cervical artery dissection ( C e AD ) worry about an increased risk for stroke in their families. The occurrence of stroke in relatives of patients with C e AD and in those with ischaemic stroke attributable to other (non‐ C e AD ) causes were compared. Methods The frequency of stroke in first‐degree relatives (family history of stroke, FHS ) was studied in IS patients ( C e AD patients and age‐ and sex‐matched non‐ C e AD patients) from the Cervical Artery Dissection and Ischemic Stroke Patients ( CADISP ) database. FHS ≤ 50 and FHS > 50 were defined as having relatives who suffered stroke at the age of ≤50 or >50 years. FHS ≤ 50 and FHS > 50 were studied in Ce AD and non‐Ce AD IS patients and related to age, sex, number of siblings, hypertension, hypercholesterolemia, smoking and body mass index ( BMI ). Results In all, 1225 patients were analyzed. FHS ≤ 50 was less frequent in Ce AD patients (15/598 = 2.5%) than in non‐Ce AD IS patients (38/627 = 6.1%) ( P = 0.003; odds ratio 0.40, 95% confidence interval 0.22–0.73), also after adjustment for age, sex and number of siblings ( P = 0.005; odds ratio 0.42, 95% confidence interval 0.23–0.77). The frequency of FHS > 50 was similar in both study groups. Vascular risk factors did not differ between patients with positive or negative FHS ≤ 50. However, patients with FHS > 50 were more likely to have hypertension and higher BMI . Conclusion Relatives of Ce AD patients had fewer strokes at a young age than relatives of non‐Ce AD IS stroke patients.