Artigo Acesso aberto Revisado por pares

Efficacy of Miltefosine for Bolivian Cutaneous Leishmaniasis

2008; American Society of Tropical Medicine and Hygiene; Volume: 78; Issue: 2 Linguagem: Inglês

10.4269/ajtmh.2008.78.210

ISSN

1476-1645

Autores

Jaime Soto, Jaime Rea, Margarita Balderrama, Julia Toledo, Paula Soto, L Valda, Jonathan Berman,

Tópico(s)

Research on Leishmaniasis Studies

Resumo

Oral miltefosine (2.5 mg/kg/d for 28 days) was compared with intramuscular antimony (20 mg/kg/d for 20 days) in the treatment of cutaneous leishmaniasis caused by Leishmania braziliensis in Palos Blancos, Bolivia. The cure rates with 6 months of follow-up were statistically similar: 36 of 41 evaluable miltefosine patients (88%) versus 15 of 16 (94%) evaluable antimony patients. However, antimony cured more rapidly, because, by 1 month after therapy, 31 of 44 miltefosine patients (70%) compared with 16 of 16 antimony patients (100%) had achieved cure. The two conclusions from this work are that oral miltefosine can be used for cutaneous disease in this part of Bolivia and that miltefosine was more effective for L. braziliensis in this region than for L. braziliensis in Guatemala. Chemotherapy needs to be evaluated in each endemic region, even if the "same" species of Leishmania causes disease in these locales.

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