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DOSE-RESPONSE CURVES FOR THE BLOOD PRESSURE EFFECTS PRODUCED BY GRADED DOSES OF L-EPINEPHRINE, A COMMERCIAL EPINEPHRINE, AND L-NOREPINEPHRINE

1952; American Society for Pharmacology and Experimental Therapeutics; Volume: 105; Issue: 2 Linguagem: Inglês

10.1016/s0022-3565(25)05018-9

1521-0103

Robert V. Brown,

Anesthesia and Sedative Agents

The data agree well with the postulate that the true dose-response curve for the pressor effects of each of the drugs is a rectangular hyperbola. A critical definition of cardiovascular sensitivity, dy/dX, is developed; the concept is tested and appears useful. Two definitions of potency are developed: the absolute potency and the dose (or response) potency. From each a potency ratio which is valid over the entire dosage range can be determined. This ratio requires no assumptions of either equality of dose or of response. It presumes that non-parallelism may be present.