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BIBTEX RIS

Expression of immune response genes in peripheral blood of cattle infested with Rhipicephalus microplus

2014; Research Foundation of Ribeirão Preto; Volume: 13; Issue: 2 Linguagem: Inglês

10.4238/2014.may.23.12

1676-5680

Robert Domingues, S. Wohlres-Viana, Daniéle Reis, Henrique Couto Teixeira, Ana Paula Ferreira, Simone Eliza Facioni Guimarães, Márcia Cristina de Azevedo Prata, John Furlong, R.S. Verneque, Marco Antônio Machado,

Animal Virus Infections Studies

The bovine tick Rhipicephalus microplus is responsible for severe economic losses in tropical cattle production.Bos indicus breeds are more resistant to tick infestations than are Bos taurus breeds, and the understanding of the physiological mechanisms involved in this difference is important for the development of new methods of parasite control.We evaluated differences in the transcript expression of genes related to the immune response in the peripheral blood of cattle previously characterized as resistant or susceptible to tick infestation.Crossbreed F2 Gir x Holstein animals (resistant, N = 6; susceptible, N = 6) were artificially submitted to tick infestation.Blood samples were collected at 0, 24, and 48 h after tick infestation and evaluated for transcript expression of the CD25, CXCL8, CXCL10, FoxP3, interleukin (IL)-10, and tumor necrosis factor alpha (TNFα) genes.Gene expression of CD25 (6.00, P < 0.01), IL-10 (31.62,P < 0.01), FoxP3 (35.48,P < 0.01), and CXCL10 (3.38, P < 0.05) was ©FUNPEC-RP www.funpecrp.com.