A controlled trial of methylene blue in severe depressive illness
1987; Elsevier BV; Volume: 22; Issue: 5 Linguagem: Inglês
10.1016/0006-3223(87)90194-6
ISSN1873-2402
AutoresG. J. Naylor, A.H.W. Smith, Peter Connelly,
Tópico(s)Optical Imaging and Spectroscopy Techniques
ResumoMethylene blue, 15 mg/day, was compared with placebo in treatment of severe depressive illness. The 3-week trial was designed to avoid bias by placebo response and also to avoid observer bias. Improvement in patients receiving methylene blue was significantly greater than in those receiving placebo. Methylene blue at a dose of 15 mg/day appears to be a potent antidepressant, and further clinical evaluation is essential.
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