Triple-layered polyurethane prosthesis with wrinkles for repairing partial tracheal defects
2014; Wiley; Volume: 124; Issue: 12 Linguagem: Inglês
10.1002/lary.24809
ISSN1531-4995
AutoresJa H. Lee, Hae S. Park, Se Heang Oh, Jin H. Lee, Jin R. Kim, Han Jo Kim, Soo Yeon Jung, Sung Min Chung, Hong Shik Choi, Han‐Soo Kim,
Tópico(s)Airway Management and Intubation Techniques
ResumoThe LaryngoscopeVolume 124, Issue 12 p. 2757-2763 Laryngology Triple-layered polyurethane prosthesis with wrinkles for repairing partial tracheal defects Ja H. Lee MD, PhD, Ja H. Lee MD, PhD Department of Otorhinolaryngology, National Health Insurance Service Ilsan Hospital, Gyeonggi-do Drs. Ja Hyun Lee and Hae Sang Park contributed equally to this work.Search for more papers by this authorHae S. Park MD, PhD, Hae S. Park MD, PhD Department of Otorhinolaryngology Head & Neck Surgery, School of Medicine, Ewha Womans University, Seoul Drs. Ja Hyun Lee and Hae Sang Park contributed equally to this work.Search for more papers by this authorSe H. Oh PhD, Se H. Oh PhD Department of Nanobiomedical Science, BK21 PLUS NBM Global Research Center for Regenerative Medicine, Dankook University, CheonanSearch for more papers by this authorJin H. Lee PhD, Jin H. Lee PhD Department of Advanced Materials, Hannam University, DaejeonSearch for more papers by this authorJin R. Kim MEng, Jin R. Kim MEng Department of Advanced Materials, Hannam University, DaejeonSearch for more papers by this authorHyun J. Kim MD, Hyun J. Kim MD Department of Otorhinolaryngology, Yonsei University, College of Medicine, Seoul, Republic of KoreaSearch for more papers by this authorSoo Y. Jung MD, Soo Y. Jung MD Department of Otorhinolaryngology Head & Neck Surgery, School of Medicine, Ewha Womans University, SeoulSearch for more papers by this authorSung M. Chung MD, PhD, Sung M. Chung MD, PhD Department of Otorhinolaryngology Head & Neck Surgery, School of Medicine, Ewha Womans University, SeoulSearch for more papers by this authorHong S. Choi MD, PhD, Hong S. Choi MD, PhD Department of Otorhinolaryngology, Yonsei University, College of Medicine, Seoul, Republic of KoreaSearch for more papers by this authorHan S. Kim MD, PhD, Corresponding Author Han S. Kim MD, PhD Department of Otorhinolaryngology Head & Neck Surgery, School of Medicine, Ewha Womans University, SeoulSend correspondence to Han Su Kim, MD, Department of Otorhinolaryngology Head & Neck Surgery, School of Medicine, Ewha Womans University Mokdong Hospital, 1071 Ahnyangcheon-Ro, Yang Cheon-Gu, Seoul, 158-710 Republic of Korea. E-mail: [email protected]; and Hong-Shik Choi, MD, Department of Otorhinolaryngology, College of Medicine, Yonsei University Gangnam Hospital, 211 Eonju-Ro, Gangnam-Gu, Seoul, 135-720 Republic of Korea. E-mail: [email protected]Search for more papers by this author Ja H. Lee MD, PhD, Ja H. Lee MD, PhD Department of Otorhinolaryngology, National Health Insurance Service Ilsan Hospital, Gyeonggi-do Drs. Ja Hyun Lee and Hae Sang Park contributed equally to this work.Search for more papers by this authorHae S. Park MD, PhD, Hae S. Park MD, PhD Department of Otorhinolaryngology Head & Neck Surgery, School of Medicine, Ewha Womans University, Seoul Drs. Ja Hyun Lee and Hae Sang Park contributed equally to this work.Search for more papers by this authorSe H. Oh PhD, Se H. Oh PhD Department of Nanobiomedical Science, BK21 PLUS NBM Global Research Center for Regenerative Medicine, Dankook University, CheonanSearch for more papers by this authorJin H. Lee PhD, Jin H. Lee PhD Department of Advanced Materials, Hannam University, DaejeonSearch for more papers by this authorJin R. Kim MEng, Jin R. Kim MEng Department of Advanced Materials, Hannam University, DaejeonSearch for more papers by this authorHyun J. Kim MD, Hyun J. Kim MD Department of Otorhinolaryngology, Yonsei University, College of Medicine, Seoul, Republic of KoreaSearch for more papers by this authorSoo Y. Jung MD, Soo Y. Jung MD Department of Otorhinolaryngology Head & Neck Surgery, School of Medicine, Ewha Womans University, SeoulSearch for more papers by this authorSung M. Chung MD, PhD, Sung M. Chung MD, PhD Department of Otorhinolaryngology Head & Neck Surgery, School of Medicine, Ewha Womans University, SeoulSearch for more papers by this authorHong S. Choi MD, PhD, Hong S. Choi MD, PhD Department of Otorhinolaryngology, Yonsei University, College of Medicine, Seoul, Republic of KoreaSearch for more papers by this authorHan S. Kim MD, PhD, Corresponding Author Han S. Kim MD, PhD Department of Otorhinolaryngology Head & Neck Surgery, School of Medicine, Ewha Womans University, SeoulSend correspondence to Han Su Kim, MD, Department of Otorhinolaryngology Head & Neck Surgery, School of Medicine, Ewha Womans University Mokdong Hospital, 1071 Ahnyangcheon-Ro, Yang Cheon-Gu, Seoul, 158-710 Republic of Korea. E-mail: [email protected]; and Hong-Shik Choi, MD, Department of Otorhinolaryngology, College of Medicine, Yonsei University Gangnam Hospital, 211 Eonju-Ro, Gangnam-Gu, Seoul, 135-720 Republic of Korea. E-mail: [email protected]Search for more papers by this author First published: 01 July 2014 https://doi.org/10.1002/lary.24809Citations: 10 This study was supported by a faculty research grant from Yonsei University College of Medicine for 2007 (6-2007-0183). The authors have no other funding, financial relationships, or conflicts of interest to disclose. Read the full textAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Abstract Objectives/Hypothesis The purpose of this study was to develop a triple-layered artificial polyurethane (PU) scaffold with a wrinkled layer for reconstruction of partial tracheal defects. Study Design Animal experiment. Methods PU/Pluronic F127 solution was transformed into an asymmetrically porous PU membrane by an immersion precipitation method. The nonporous wrinkled film was prepared by a simple casting of the PU solution on a grooved mold. The triple-layered wrinkled PU scaffolds were fabricated by simple inosculating between the wrinkled film and the porous membranes as in a sandwich (porous/wrinkled/porous structure). Scaffolds were transplanted into 10 New Zealand rabbits after creating tracheal windows. Endoscopic and histological examinations and mechanical tests were performed. Results The thickness and outer pore size of the prepared triple-layered PU scaffold were ∼1.95 mm and ∼200 μm, respectively. The wrinkled PU scaffold showed better maximum flexural strength compared to the nonwrinkled scaffold (1.03 ± 0.19 vs. 0.56 ± 0.09 MPa). Eight of 10 rabbits survived through all of the examinations and procedures. Endoscopic findings revealed that respiratory mucosa was observed over the scaffold at 3 weeks, and it was an entirely covered scaffold at 6 weeks. The circular framework of the tracheal lumen was maintained in seven of 10 rabbits. Histologic findings showed that ciliated respiratory mucosa covered the surface of the scaffolds. The tensile strength of the scaffold-implanted trachea was lower than that of the normal control. Conclusions A wrinkled, triple-layered PU scaffold can be used as a ready-made scaffold for reconstruction of partial tracheal defects. Level of Evidence NA Laryngoscope, 124:2757–2763, 2014 Citing Literature Volume124, Issue12December 2014Pages 2757-2763 RelatedInformation
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