PANCREATIC SECRETION IN MAN AFTER STIMULATION WITH SECRETIN AND ACETYLBETAMETHYLCHOLINE CHLORIDE
1940; Volume: 66; Issue: 3 Linguagem: Inglês
10.1001/archinte.1940.00190150159012
ISSN0730-188X
Autores Tópico(s)Vagus Nerve Stimulation Research
ResumoSecretory activity of the pancreas may be stimulated by either a humoral (secretin) or a neural (vagal) mechanism. The amount and type of secretion produced by the two mechanisms has been shown to differ widely in animals. Stimulation with secretin produces a large volume of pancreatic juice rich in bicarbonate and poor in enzymes, whereas vagal stimulation produces a scant flow of juice poor in bicarbonate and rich in enzymes. Mellanby 1 hypothesized that the content of enzymes in the pancreatic juice is determined by action of the vagus nerves, whereas the concentration of the bicarbonate solution in which these enzymes are contained is determined by the action of secretin. In a clinical study of pancreatic function, the response of the pancreas to both types of stimulants should be determined in order to obtain a complete picture. In man, the effect of intravenous injection of purified secretin was first studied,
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