Construction of Quaternary Stereocenters by Efficient and Practical Conjugate Additions to α,β‐Unsaturated Ketones with a Chiral Organic Catalyst
2005; Wiley; Volume: 45; Issue: 6 Linguagem: Inglês
10.1002/anie.200502658
ISSN1521-3773
AutoresFanghui Wu, Hongming Li, Ran Hong, Li Deng,
Tópico(s)Synthetic Organic Chemistry Methods
ResumoAdded value: The conjugate addition of cyclic or acyclic α-substituted β-ketoesters to α,β-unsaturated ketones using a chiral organic catalyst (1) can be achieved with good enantioselectivity, diastereoselectivity, and yield. This asymmetric CC bond formation strategy provides a range of chiral building blocks 2 that contain an all-carbon quaternary stereocenter.
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