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ADDITIONAL EVIDENCE FOR CHROMOSOME ABNORMALITIES IN THE ERYTHROID PRECURSORS IN ACUTE LEUKAEMIA

1971; Wiley; Volume: 189; Issue: 1-6 Linguagem: Inglês

10.1111/j.0954-6820.1971.tb04345.x

0001-6101

Mogens Krogh Jensen, Sven‐Aage Killmann,

Erythrocyte Function and Pathophysiology

Abstract. In continuation of a previous study, five additional patients with acute leukaemia have been studied, characterized by abnormal bone marrow karyotypes and fairly well represented erythropoiesis. In all five patients the percentage of erythroblast mitoses (16–62% of the bone marrow mitoses) was definitely higher than that of normal metaphases. These data confirm the previous results and suggest that, in acute myeloid leukaemia, the chromosome abnormalities are not confined to the cells of the blastic variety, but are also present in the erythroid precursors. Thus acute myeloid leukaemia is probably not a disease of the granulocytic cell line, but rather a disorder of haemopoiesis in general.