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Human papillomavirus infection and other risk factors for cervical intraepithelial neoplasia in Japan

1999; Springer Nature; Volume: 80; Issue: 3-4 Linguagem: Inglês

10.1038/sj.bjc.6690401

1532-1827

Hiroyuki Yoshikawa, Chisato Nagata, K Noda, Shunsuke Nozawa, A Yajima, Souei Sekiya, Hajime Sugimori, Yasuo Hirai, K Kanazawa, Motoyasu Sugase, Hiroyuki Shimizu, Takashi Kawana,

Cervical Cancer and HPV Research

Various risk factors were investigated in 167 cervical intra-epithelial neoplasia (CIN) case and control pairs in Japan. CIN cases showed evidence of nine known risk factors including smoking and sexual behaviour. However, after adjustment for papillomavirus infection, the highest determinant, the only remaining risk factors were: being married, early age at first pregnancy and multiparity.