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HLA-DR Expression in Acute Pancreatitis

1999; Oxford University Press; Volume: 165; Issue: 10 Linguagem: Inglês

10.1080/110241599750008053

1741-9271

A. Richter, Th. Nebe, K. Wendl, K. L. Schuster, G. Klaebisch, Michael Quintel, Dietmar Lorenz, Stefan Post, M. Trede,

Diabetes and associated disorders

To investigate the role of the monocyte/macrophage system in acute pancreatitisProspective clinical studyUniversity clinic, Germany37 consecutive patients who presented with acute pancreatitis.Correlation between function of monocytes measured by HLA-DR expression and outcomePatients were divided into three groups according to outcome: those with severe pancreatitis who died (n = 10), those with severe pancreatitis who survived (n = 15), and those with mild pancreatitis who survived (n = 12). There was a clear and significant difference between those with severe and those with mild disease. HLA-DR expression was initially depressed in both groups, but after the third day of treatment it started to recover significantly in those with mild disease (p < 0.05). The difference was also significant from day 7 onwards between those with severe disease who died and those with severe disease who survived (p < 0.05).Monocyte function as measured by HLA-DR expression (CD14+DR+) is reduced in patients with acute pancreatitis and does not recover in patients who are going to die (median < 20 relative antigen density units; RU).