ChIPCodis: mining complex regulatory systems in yeast by concurrent enrichment analysis of chip-on-chip data
2008; Oxford University Press; Volume: 24; Issue: 9 Linguagem: Inglês
10.1093/bioinformatics/btn094
ISSN1367-4811
AutoresFederico Abascal, Pedro Carmona‐Sáez, J.M. Carazo, Alberto Pascual-Montano,
Tópico(s)Microbial Metabolic Engineering and Bioproduction
ResumoAbstract Motivation: Eukaryotic genes are often regulated by multiple transcription factors (TFs). Depending on the interactions among different TFs the expression of a gene can be tuned to respond to diverse environmental conditions. Chip-on-chip experiments provide a snapshot of which TF are in vivo bound to which genes in a particular condition, and have been applied to characterize the regulatory code of yeast under several experimental settings. ChIPCodis mines this data to provide new insights about how the expression of a particular group of genes is regulated. For a given list of yeast genes ChIPCodis determines which combinations of TFs are significantly over-represented in a series of environmental conditions. Availabilty: http://chipcodis.dacya.ucm.es Contact: pascual@fis.ucm.es Supplementary information: http://chipcodis.dacya.ucm.es/sm.html
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