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Erythropoietin prevents the acute myocardial inflammatory response induced by ischemia/reperfusion via induction of AP-1

2005; Oxford University Press; Volume: 65; Issue: 3 Linguagem: Inglês

10.1016/j.cardiores.2004.11.019

1755-3245

Tao Rui, Qingping Feng, Man-Ping Lei, Tianqing Peng, Jianyun Zhang, Mingming Xu, E. Dale Abel, Anargyros Xenocostas, Peter R. Kvietys,

Cardiac Ischemia and Reperfusion

Objective: Erythropoietin (EPO) prevents the myocardial dysfunction induced by ischemia/reperfusion (I/R). Since I/R-induced myocardial dysfunction is associated with an acute inflammatory response, we assessed the anti-inflammatory properties of EPO using in vitro and in vivo models of I/R.