Oral Administration of β‐Lactamase Preserves Colonization Resistance of Piperacillin‐Treated Mice
2003; Oxford University Press; Volume: 188; Issue: 10 Linguagem: Inglês
10.1086/379153
ISSN1537-6613
AutoresUsha Stiefel, Nicole J. Pultz, Jaana Harmoinen, Pertti Koski, Kai Lindevall, Marion S. Helfand, Curtis J. Donskey,
Tópico(s)Clostridium difficile and Clostridium perfringens research
ResumoWe hypothesized that orally administered, recombinant class A β-lactamase would inactivate the portion of parenteral piperacillin excreted into the intestinal tract, preserving colonization resistance of mice against nosocomial pathogens. Subcutaneous piperacillin or piperacillin plus oral β-lactamase were administered 24 and 12 h before orogastric inoculation of piperacillin-resistant pathogens. Oral administration of β-lactamase reduced piperacillin-associated alteration of the indigenous microflora and prevented overgrowth of pathogens
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