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Estrogen receptor ligands. Part 9: Dihydrobenzoxathiin SERAMs with alkyl substituted pyrrolidine side chains and linkers

2004; Elsevier BV; Volume: 15; Issue: 1 Linguagem: Inglês

10.1016/j.bmcl.2004.10.036

1464-3405

Timothy A. Blizzard, Frank DiNinno, Jerry D. Morgan, Helen Y. Chen, Jane Y. Wu, Seongkon Kim, Wanda Chan, Elizabeth T. Birzin, Yi Yang, Lee-Yuh Pai, Paula M.D. Fitzgerald, Nandini Sharma, Ying Li, Zhoupeng Zhang, Edward C. Hayes, Carolyn DaSilva, Wei Tang, Susan P. Rohrer, James M. Schaeffer, Milton L. Hammond,

Ferrocene Chemistry and Applications

A series of dihydrobenzoxathiin SERAMs with alkylated pyrrolidine side chains or alkylated linkers was prepared. Minor modifications in the side chain or linker resulted in significant effects on biological activity, especially in uterine tissue.