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The toxicology and safety of apple polyphenol extract

2004; Elsevier BV; Volume: 42; Issue: 6 Linguagem: Inglês

10.1016/j.fct.2004.02.008

1873-6351

Toshihiko Shoji, Yoko Akazome, T Kanda, Mitsuo Ikeda,

Ginkgo biloba and Cashew Applications

Apple polyphenol extract has strong antioxidant activity and various physiological functions, and is used in Japan as a food additive and nutritional supplements. Here, we tested the consumption safety of Applephenon, which is a polyphenol extract produced from unripe apples. The Ames test without S9 mixture revealed that Applephenon, had slight mutagenicity at a high concentration of 2500 microg/plate; however, both chromosomal aberration test and the micronucleus test found no significant mutagenicity. Furthermore, an acute oral-toxicity test, and a 90-day subchronic-toxicity test showed no significant hematological, clinical, chemical, histopathological, or urinary effects at a dose of 2000 mg/kg. These results confirm that Applephenon is safe and no toxic at average dietary level.