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Selective silencing of Na V 1.7 decreases excitability and conduction in vagal sensory neurons

2011; Wiley; Volume: 589; Issue: 23 Linguagem: Inglês

10.1113/jphysiol.2011.215384

1469-7793

Yukiko Muroi, Fei Ru, Marián Kollárik, Brendan J. Canning, Stephen Hughes, Stacey L. Walsh, Martin Sigg, Michael Carr, Bradley J. Undem,

Vagus Nerve Stimulation Research

Non‐technical summary Sodium channels are obligatory for the conduction of action potentials along axons. There are several different sodium channel subtypes expressed in vagal sensory neurons, and it is difficult to pharmacologically block these subtypes selectively. We used virally delivered shRNA to selectively block the production of one of the sodium channel subtypes expressed in vagal sensory neurons, namely Na V 1.7, and found that by selectively inhibiting the expression of this channel the conduction of action potentials was blocked in the majority of vagal sensory neurons. This study also shows that Na V 1.7 is required for the elicitation of classical vagal reflexes such as cough.