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oPOSSUM-3: Advanced Analysis of Regulatory Motif Over-Representation Across Genes or ChIP-Seq Datasets

2012; Genetics Society of America; Volume: 2; Issue: 9 Linguagem: Inglês

10.1534/g3.112.003202

2160-1836

Andrew T. Kwon, David J. Arenillas, Rebecca Worsley Hunt, Wyeth W. Wasserman,

Genomics and Phylogenetic Studies

oPOSSUM-3 is a web-accessible software system for identification of over-represented transcription factor binding sites (TFBS) and TFBS families in either DNA sequences of co-expressed genes or sequences generated from high-throughput methods, such as ChIP-Seq. Validation of the system with known sets of co-regulated genes and published ChIP-Seq data demonstrates the capacity for oPOSSUM-3 to identify mediating transcription factors (TF) for co-regulated genes or co-recovered sequences. oPOSSUM-3 is available at http://opossum.cisreg.ca.